Pimozide and Thioridazine: Drugs that prolong the Q-T interval (a measurement on an electrocardiogram, or ECG, that represents how long it takes the body to recharge between heartbeats) can increase the risk of serious heart arrhythmias and sudden death when patients also take Prozac. Some antidepressants and opioids: Drugs including duloxetine, opioids, tricyclic antidepressants and haloperidol (that the enzyme CYP2D6 metabolizes in the body) may cause too much medication to remain in the body when patients are also taking Prozac. 
Electroconvulsive Therapy (ECT): May cause prolonged seizures. John’s Wort, when combined with Prozac, may also increase the risk. Serotonergic drugs: Medications like monoamine oxidase inhibitors, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone and amphetamines can increase the risk of serotonin syndrome when taken with Prozac. NSAIDS, aspirin and warfarin: Drugs that interfere with hemostasis may increase the risk of gastrointestinal bleeding when taken with Prozac. Our writers are members of professional associations, including American Medical Writers Association, American Bar Association, The Alliance of Professional Health Advocates and International Society for Medical Publication Professionals. The information on has been medically and legally reviewed by more than 30 expert contributors, including doctors, pharmacists, lawyers, patient advocates and other health care professionals. This means the high-quality information we provide comes from credible sources, such as peer-reviewed medical journals and expert interviews. is HONCode (Health On the Net Foundation) certified. Our team includes experienced medical writers, award-winning journalists, researchers and certified medical and legal experts. 
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